A microfluid test-bed with nanopore membranes for in-vitro simulation of flow characteristics of glaucoma drainage devices

Author

Pan, Tingrui ; Brown, J. David ; Ziaie, Babak

Author_Institution

Dept. of Electr. & Comput. Eng., Minnesota Univ., USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

1830

Abstract

In this paper, we report on a microfluidic test-bed for in-vitro simulation of flow characteristics of valved-glaucoma drainage devices. A nanopore membrane is used to mimic the fibrous tissue encapsulation of the sub-conjunctival plate following surgery. Pressure measurements with and without the valve clearly demonstrated the persisting effect of the microvalve in regulating the intraocular pressure subsequent to the fibrous capsule formation.

Keywords

diseases; eye; membranes; microfluidics; patient treatment; pressure control; pressure measurement; fibrous tissue encapsulation; flow characteristics; glaucoma drainage devices; in-vitro simulation; intraocular pressure regulation; microfluid test-bed; nanopore membranes; persisting effect; subconjunctival plate; valve; Biomembranes; Encapsulation; In vitro; Microfluidics; Microvalves; Nanoporous materials; Pressure measurement; Surgery; Testing; Valves;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053048

Filename

1053048