Title :
Construction of a 3D model of human lens fiber major intrinsic protein (MIP or AQP0) from human aquaporin-1 (AQP1)
Author :
Yao, Jianchao ; Fung, Peter C W ; Chan, Francis H Y
Author_Institution :
Dept. of Electr. & Electron. Eng., Hong Kong Univ., China
Abstract :
We propose a 3D model of human lens fiber major intrinsic protein (MIP or AQP0), based on comparative modeling using human AQP1 as a template. The validation of the generated model was done with the Swiss-PdbViewer program and the stereochemical quality of the model was verified with the PROCHECK program. The model can be of help in the research of relationship between human MIP and human cataracts.
Keywords :
biochemistry; eye; physiological models; proteins; vision defects; AQP0; PROCHECK; Swiss-Pdbviewer; comparative modeling; generated model validation; human AQP1; human cataracts; human lens fiber major intrinsic protein; model stereochemical quality; Amino acids; Biomembranes; Cells (biology); Databases; Genetic mutations; Humans; Lenses; Pathology; Physiology; Protein engineering;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1053242
