A mechanistic model of myogenic response

Author

Yang, J. ; Clark, J.W. ; Bryan, R. ; Robertson, C.

Author_Institution

Rice Univ., Houston, TX, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2680

Abstract

We develop an integrated model of a small arterial resistance vessel, which can mimic its major property of blood flow autoregulation. In the current model, we embed the smooth muscle cell model in a larger compliance-based arterial wall model. The integrated model is used to mimic published pressure-vessel diameter data obtained from isolated resistance vessels that are mounted in a hydraulic test apparatus. The model provides biophysically based insights into the myogenic mechanism as it responds to changes in transmural pressure, in the presence and absence of Ca²⁺ blockers. It mimics measured data very well and provides a model that is able to link events at subcellular level to macroscopic changes in vessel diameter.

Keywords

biomembrane transport; blood vessels; muscle; physiological models; Ca; Ca²⁺ blockers; biophysically based insights; compliance-based arterial wall model; hydraulic test apparatus; isolated resistance vessels; macroscopic vessel diameter changes; published pressure-vessel diameter data; small arterial resistance vessel; subcellular level events; Arteries; Blood flow; Circuits; Educational institutions; Electrical resistance measurement; Immune system; Mathematical model; Muscles; Testing; Time varying systems;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053489

Filename

1053489