A mechanistic model of myogenic response

We develop an integrated model of a small arterial resistance vessel, which can mimic its major property of blood flow autoregulation. In the current model, we embed the smooth muscle cell model in a larger compliance-based arterial wall model. The integrated model is used to mimic published pressure-vessel diameter data obtained from isolated resistance vessels that are mounted in a hydraulic test apparatus. The model provides biophysically based insights into the myogenic mechanism as it responds to changes in transmural pressure, in the presence and absence of Ca²⁺ blockers. It mimics measured data very well and provides a model that is able to link events at subcellular level to macroscopic changes in vessel diameter.