• DocumentCode
    385309
  • Title

    Near real time confocal imaging of dysplasia in the oral cavity

  • Author

    Clark, A.L. ; Gillenwater, A. ; Collier, T. ; Alizadeh-Naderi, R. ; El-Naggar, A.K. ; Richards-Kortum, R.

  • Author_Institution
    Dept. of Biomed. Eng., Texas Univ., Austin, TX, USA
  • Volume
    2
  • fYear
    2002
  • fDate
    2002
  • Firstpage
    982
  • Abstract
    The use of high resolution, in vivo confocal imaging may offer a clinical tool to detect early neoplasia and reduce the incidence and mortality of cancer. Our laboratory is currently examining the feasibility of using confocal microscopy for non-invasive diagnosis of dysplasia and early carcinoma in the oral cavity. This study uses a near real time reflectance confocal microscope to acquire images at various depths throughout the epithelial layer. To date, we have examined data from twelve of an approved twenty-two patient study in the oral cavity. Our initial results demonstrate the confocal microscope´s ability to image sub-cellular morphology with a resolution allowing differentiation between normal and dysplastic tissue. These results support this technique´s potential for in vivo assessment of dysplasia within the oral cavity.
  • Keywords
    biomedical optical imaging; cancer; cellular biophysics; image resolution; optical microscopy; cancer detection; cancer mortality; clinical tool; confocal microscopy; epithelial layer; epithelial malignancies; near real time reflectance confocal microscope; neoplasia; noninvasive diagnosis; normal tissue; oral cavity; subcellular morphology imaging; Biomedical imaging; Biopsy; Cancer; Focusing; Head; Image resolution; Laboratories; Microscopy; Neck; Oncological surgery;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
  • ISSN
    1094-687X
  • Print_ISBN
    0-7803-7612-9
  • Type

    conf

  • DOI
    10.1109/IEMBS.2002.1106236
  • Filename
    1106236