Extraction of transient MR signal responses in a hyperoxia model using independent component analysis

The effects of hyperoxia to neurovasculature were investigated using a mouse brain as a physiological model. Pure oxygen was applied to the mouse respiratory system to induce hyperoxia in the brain. Physiological alterations were acquired using a 9.4 T magnetic resonance imaging (MRI). Independent component analysis (ICA) and principal component analysis (PCA) were applied to the time-series MRI data to extract the transient hyperoxic responses. ICA and PCA successfully extracted the transient hyperoxic responses and localized similar affected areas. ICA, however, could provide a better signal extraction than PCA in terms of wave-shape.