Title :
Three-dimensional model of cardiac electromechanics: cell to organ
Author :
Usyk, Taras P. ; Belik, Mary Ellen ; Michailova, Anushka ; McCulloch, Andrew D.
Author_Institution :
Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA
Abstract :
We describe a new computational model that integrates the cellular biophysics of ventricular myocytes into structurally detailed three-dimensional models of the ventricular walls during the whole cardiac cycle. The new model is suitable for investigating hypotheses regarding excitation-contraction coupling in the intact heart.
Keywords :
bioelectric phenomena; biomechanics; cardiology; cellular biophysics; finite element analysis; physiological models; cardiac electromechanics; complex interactions; congestive heart failure; coronary heart disease; crossbridge kinetics; electrical behavior; excitation-contraction coupling; heart diseases; intracellular calcium cycling; mechanical behavior; mechanoelectric feedback; transmembrane ionic currents; ventricular arrhythmias; ventricular myocytes; ventricular walls; Biomedical engineering; Calcium; Cellular biophysics; Computational modeling; Couplings; Finite element methods; Heart; Hemodynamics; Kinetic theory; Solid modeling;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106357
