Title :
Remodeling and elasticity changes in human vein grafts
Author :
Jacot, J.G. ; Abduah, I. ; Belkin, M. ; Donaldson, M.C. ; Whittemore, A.D. ; Conte, M.S.
Author_Institution :
Dept. of Biomed. Eng., Boston Univ., MA, USA
Abstract :
Duplex ultrasound measurements of patients (N=65) undergoing lower extremity bypass with autologous veins were taken at surgery and multiple times after surgery. Changes in lumen diameter were correlated with changes in external graft diameter (p<0.001) but not with wall area. Changes in lumen diameter were also negatively correlated with initial lumen diameter (p<0.05). Grafts showed a marked increase in wall elastic modulus between 1 and 3 months postoperatively. In this same time, graft wall tension decreased to a level not significantly different to that in the normal superficial femoral artery (SFA). These results suggest complex remodeling of vein grafts with wall growth that alleviates wall tension, independent from changes in lumenal diameter.
Keywords :
biomechanics; biomedical ultrasonics; blood vessels; elasticity; surgery; autologous veins; complex remodeling; duplex ultrasound measurements; elasticity changes; external graft diameter; graft wall tension; human vein grafts; initial lumen diameter; lower extremity bypass; lumen diameter; multiple times; normal superficial femoral artery; patients; surgery; vein bypass grafting; wall area; wall elastic modulus; wall growth; Elasticity; Extremities; Humans; Image segmentation; Pulse measurements; Surgery; Thickness measurement; Ultrasonic imaging; Ultrasonic variables measurement; Veins;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106410
