Dynamical instability of cardiac action potentials: cause and effect

Author

Otani, Niels F. ; Li, Mingyi

Author_Institution

Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA

Volume

2

fYear

2002

fDate

2002

Firstpage

1358

Abstract

An eigenmode method is used to develop insight into the mechanism behind alternans, memory, and conserved and nearly-conserved quantities in small cardiac preparations undergoing constant pacing. The time course of the right eigenmodes of perturbations about the steady state determine the process by which alternans and memory are produced. The left eigenvalues define the conservation and near-conservation laws. Matrix "cleaning" techniques further clarify the stability of action potentials during constant pacing.

Keywords

bioelectric potentials; eigenvalues and eigenfunctions; electrocardiography; matrix algebra; medical signal processing; physiological models; stability; alternans; cardiac action potentials; cardiac electrophysiology; conservation laws; constant pacing; dynamical instability; eigenmode analysis; eigenvalues; electrophysiology; matrix cleaning techniques; memory; near-conservation laws; perturbations; small cardiac preparations; Acceleration; Biomedical engineering; Biomembranes; Eigenvalues and eigenfunctions; Mathematical programming; Morphology; Multidimensional systems; Stability; Steady-state;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106427

Filename

1106427