Title :
Comparison of three biphasic defibrillation waveforms: Gurvich waveform is more efficient
Author :
Qu, F. ; Nikolski, V.P. ; Wollenzier, B.R. ; Efimov, I.R.
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
The biphasic waveform has greater defibrillation efficacy than the monophasic waveform. Yet, the optimal type of biphasic defibrillation waveform is still unknown. Our objective was to compare the defibrillation efficacy of three morphologically different biphasic waveforms (named as truncated exponential waveform, modified Zoll waveform, and Gurvich waveform) in an isolated Langendorff perfused rabbit heart. Optical potential mapping techniques were used. The result showed that the Gurvich waveform has the lowest defibrillation threshold (DFT). A multiple comparison test showed that there is a significant difference of DFTs between the modified Zoll waveform and Gurvich waveform (mean±SE: 0.31±0.03 J and 0.25±0.02 J, p<0.02). We also examined the change of membrane potential caused by shocks. The result showed an homogeneous response for different waveforms.
Keywords :
bioelectric potentials; biomembrane transport; cardiology; defibrillators; waveform analysis; Gurvich waveform; defibrillation efficacy; defibrillation threshold; epicardial transmembrane potentials; homogeneous response; isolated Langendorff perfused rabbit heart; membrane potential; modified Zoll waveform; monophasic waveform; morphologically different biphasic waveforms; multiple comparison test; optical potential mapping techniques; optimal type; shocks; three biphasic defibrillation waveforms; truncated exponential waveform; Analysis of variance; Biomedical engineering; Biomedical optical imaging; Biomembranes; Defibrillation; Electric shock; Heart; Myocardium; Shape; Testing;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106471