DocumentCode :
385507
Title :
Mechanics and gas mixing in constricted lungs
Author :
Wilson, T.A. ; Anafi, R.C. ; Beck, K.C.
Author_Institution :
Dept. of Aerosp. Eng. & Mech., Minnesota Univ., Minneapolis, MN, USA
Volume :
2
fYear :
2002
fDate :
2002
Firstpage :
1462
Abstract :
Lung elastance, resistance, and the concentration of He in expired gas were measured simultaneously during He washin maneuvers in 5 normal subjects with increasing doses of methacholine delivered by aerosol. A model for the mechanics of constricted airways was tested against these data. The model predicts two states for the constricted airway, one nearly open and one nearly closed. With increasing smooth muscle activation, the fraction of the peripheral airways in the nearly closed state increases. As a result, elastance and resistance increase and ventilation becomes more nonuniform. The predictions of the model agree well with both the mechanics and the gas mixing data.
Keywords :
aerosols; elasticity; mixing; physiological models; pneumodynamics; He; He concentration; constricted lungs; gas mixing; lung elastance; lung impedance; lung resistance; mechanical model; methacholine dose; nearly closed airway; nearly open airway; normal human subjects; peripheral airways fraction; smooth muscle activation; transpulmonary pressure; ventilation; Aerosols; Helium; Humans; Immune system; Impedance; Lungs; Mechanical variables measurement; Muscles; Predictive models; Stress;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
ISSN :
1094-687X
Print_ISBN :
0-7803-7612-9
Type :
conf
DOI :
10.1109/IEMBS.2002.1106484
Filename :
1106484
Link To Document :
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