Title :
The unifying role of cytoskeletal prestress in micromechanics of the adherent cell
Author :
Stamenovic, D. ; Tolic-Norrelykke, I.M. ; Fredberg, J.J. ; Wang, N.
Author_Institution :
Dept. of Biomed. Eng., Boston Univ., MA, USA
Abstract :
We measured cytoskeletal prestress and stiffness in cultured airway smooth muscle cells treated with graded doses of histamine and isoproterenol, and with colchicine. The stiffness increased in proportion with increasing prestress. This feature is the hallmark of systems known as stress-supported structures. In addition, microtubules balanced a substantial, but relatively small fraction of the prestress.
Keywords :
adhesion; biomechanics; cellular biophysics; elasticity; lung; muscle; cell shape alterations; cellular biomechanics; coichicine; cultured airway smooth muscle cells; cytoskeletal prestress; histamine; isoproterenol; microtubules; stress-supported structures; Biomedical engineering; Biomedical measurements; Biomembranes; Cells (biology); Medical treatment; Muscles; Public healthcare; Resists; Shape; Tensile stress;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106486
