Closed-loop fuzzy control of resuscitation of hemorrhagic shock in sheep

Fluid therapy of severe hemorrhage and trauma can be life saving, but can also be life threatening if the volume delivered is either inadequate or excessive. Unfortunately, expert caregivers often do not have the time to focus on controlling fluid infusion rate due to the necessity of dealing with other critical tasks. We describe an automated closed-loop resuscitation system that uses a fuzzy logic controller to adjust infusion rate based on arterial pressure. The system was used to successfully resuscitate hemorrhaged sheep.