Abstract :
Cytochrome c oxidase is discussed as a possible photoacceptor when cells are irradiated with monochromatic red to near-IR radiation. Five primary action mechanisms are reviewed: changes in the redox properties of the respiratory chain components following photoexcitation of their electronic states, generation of singlet oxygen, localized transient heating of absorbing chromophores, NO release from catalytic center of cytochrome c oxidase, and increased superoxide anion production with subsequent increase in concentration of the product of its dismutation, H2O2. A cascade of reactions connected with alteration in cellular homeostasis parameters (pHi, [Cai], cAMP, Eh, [ATP] and as well as NF - κB, AP-1) is considered as a photosignal transduction and amplification chain in a cell (secondary mechanisms).
Keywords :
biochemistry; biological effects of laser radiation; cellular effects of radiation; laser applications in medicine; radiation therapy; NO release; absorbing chromophores; catalytic center; cell irradiation; cellular homeostasis parameters; cellular mechanisms; cytochrome c oxidase; dismutation product concentration; electronic state photoexcitation; localized transient heating; low power laser therapy; monochromatic red radiation; near-IR radiation; photoacceptor; photosignal transduction amplification chain; primary action mechanisms; reaction cascade; redox properties; respiratory chain components; secondary mechanisms; singlet oxygen generation; superoxide anion production; Chemical lasers; Fiber lasers; Heating; Laser ablation; Laser theory; Mechanical factors; Medical treatment; Power lasers; Production; Semiconductor lasers;
