Microbead immunoassay dipstick system (MIDS)

Author

Colston, Bill ; Visuri, Steve ; Mcbride, M. ; Rao, Rupa ; Richards, Jim ; Chuang, Frank ; Chang, John ; Carlson, James ; Derlet, Robert

Author_Institution

Lawrence Livermore Nat. Lab., CA, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

363

Abstract

Summary form only given. We have developed a prototype system for reducing Luminex based immunoassay technology to a portable, customizable platform that can perform multiplexed assays on location - independent of clinical laboratory support. In principle, this device can be used to test for any biomolecular interaction in which strong binding occurs, including receptor-ligand coupling, enzyme-substrate binding, antibody-antigen interactions, and nucleic acid (DNA) hybridization reactions. Since an overwhelming majority of clinical laboratory tests are based on antibody-antigen interactions, however, we have focusing our initial efforts on multiplexed immunoassay detection.

Keywords

biochemistry; biological specimen preparation; biological techniques; molecular biophysics; patient diagnosis; DNA hybridization reactions; Luminex based immunoassay technology; antibody-antigen interactions; biomolecular interaction; clinical applications; disposable sample preparation; enzyme-substrate binding; microbead immunoassay dipstick system; multiplexed assays; multiplexed immunoassay detection; pathogen specific optically encoded microbead templates; portable customizable platform; receptor-ligand coupling; strong binding; Contamination; Fungi; Immune system; Instruments; Laboratories; Microorganisms; Pathogens; Protocols; Testing; Viruses (medical);

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics Society, 2002. LEOS 2002. The 15th Annual Meeting of the IEEE

ISSN

1092-8081

Print_ISBN

0-7803-7500-9

Type

conf

DOI

10.1109/LEOS.2002.1134080

Filename

1134080