Title :
A System for the Determination of Planar Lipid Bilayer Breakdown Voltage and Its Applications
Author :
Peter Kramar;Damijan Miklavcic;Alenka Macek Lebar
Author_Institution :
Fac. of Electr. Eng., Univ. of Ljubljana, Ljubljana, Slovenia
Abstract :
In this paper, we focus on measurement principles used in electroporation studies on planar lipid bilayers. In particular, we point out the voltage-clamp measurement principle that has great importance when the breakdown voltage of a planar lipid bilayer is under consideration; however, it is also appropriate for the determination of other planar lipid bilayer electrical properties such as resistance and capacitance. A new experimental system that is based on the voltage-clamp measurement principle is described. With the use of a generator that can generate arbitrary-type signals, many specific shapes of a voltage signal could be generated, and therefore, the experimental system is appropriate for a broad spectrum of measurements.
Keywords :
"Lipidomics","Biomembranes","Cells (biology)","Electrical resistance measurement","Capacitance measurement","Electric resistance","Shape measurement","Breakdown voltage","Electric variables measurement","Immune system"
Journal_Title :
IEEE Transactions on NanoBioscience
DOI :
10.1109/TNB.2009.2022834