DocumentCode :
386405
Title :
Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus
Author :
Upton, M.L. ; Chen, Jiann-Jong ; Guilak, F. ; Setton, L.A.
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Volume :
1
fYear :
2002
fDate :
2002
Firstpage :
438
Abstract :
The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.
Keywords :
biological tissues; biomechanics; genetics; orthopaedics; proteins; biologically active tissue; decreased mRNA levels; increased mRNA levels; joint stability; knee; load distribution; matrix protein gene expression inhibition; mechanical stimuli; orthopedic biomechanics; static compression; transcriptional level; type I collagen; Biomedical engineering; Compressive stress; Fluorescence; Gene expression; Joints; Knee; Orthopedic surgery; Protein engineering; RNA; Tensile stress;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
ISSN :
1094-687X
Print_ISBN :
0-7803-7612-9
Type :
conf
DOI :
10.1109/IEMBS.2002.1136884
Filename :
1136884
Link To Document :
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