Title :
Adaptation of a single trabecula to a changing stress environment
Author :
Be´ery, M. ; Gefen, A.
Author_Institution :
Dept. of Biomed. Eng., Tel Aviv Univ., Israel
Abstract :
In this study, a mathematical model of a single trabecula was developed to simulate its long-term adaptive response in a changing stress environment. The model incorporates an osteocyte mechanosensing network that regulates the morphology and tissue material behavior of the trabecula. The adaptation response was shown to be most sensitive to changes in bending moments acting on the trabecula´s boundaries, and a decrease of more than 57% in their value caused thinning of the trabecular profiles.
Keywords :
bending; biocontrol; biomechanics; bone; feedback; mechanoception; physiological models; adaptation feedback; bending moments; boundaries; changing stress environment; long-term adaptive response; mathematical model; morphology; osteocyte mechanosensing network; single trabecula adaptation; thinning; tissue material behavior; tissue-level modeling; trabecular profiles; Biomedical optical imaging; Cancellous bone; Lattices; Mathematical model; Optical microscopy; Optical sensors; Predictive models; Shape; Stress; Surface morphology;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136894
