Bioerodible polyanhydrides with tailored microstructure for controlled drug delivery

Author

Narasimhan, Balaji ; Kipper, Matt ; Larobina, Domenico ; Mensitieri, Giuseppe

Author_Institution

Dept. of Chem. Eng., Iowa State Univ., Ames, IA, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

468

Abstract

In this work we summarizes a comprehensive study of a drug delivery system based on bioerodible polyanhydrides. The polymer system is composed of the copolymer poly[1,6-bis(p-carboxy phenoxy)hexane-cosebacic anhydride] (poly(CPH-SA)). This system has been characterized by its microstructure, erosion behavior, and monomer/drug release kinetics. It is shown that drugs thermodynamically partition into the micro-phases of heterogeneous copolymers. A predictive model has been developed which describes the drug and monomer release kinetics and comparisons to in vitro release studies provide important insights into the mechanism of release.

Keywords

drug delivery systems; polymer blends; bioerodible polyanhydrides; controlled drug delivery; erosion behavior; heterogeneous copolymers; in vitro release studies; monomer release kinetics; poly[1,6-bis(p-carboxy phenoxy)hexane-cosebacic anhydride]; release mechanism; tailored microstructure; thermodynamic partitioning; Amorphous materials; Atomic force microscopy; Control systems; Crystal microstructure; Crystallization; Drug delivery; Kinetic theory; Polymers; Presence network agents; Thermal degradation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1136899

Filename

1136899