Title :
Bioerodible polyanhydrides with tailored microstructure for controlled drug delivery
Author :
Narasimhan, Balaji ; Kipper, Matt ; Larobina, Domenico ; Mensitieri, Giuseppe
Author_Institution :
Dept. of Chem. Eng., Iowa State Univ., Ames, IA, USA
Abstract :
In this work we summarizes a comprehensive study of a drug delivery system based on bioerodible polyanhydrides. The polymer system is composed of the copolymer poly[1,6-bis(p-carboxy phenoxy)hexane-cosebacic anhydride] (poly(CPH-SA)). This system has been characterized by its microstructure, erosion behavior, and monomer/drug release kinetics. It is shown that drugs thermodynamically partition into the micro-phases of heterogeneous copolymers. A predictive model has been developed which describes the drug and monomer release kinetics and comparisons to in vitro release studies provide important insights into the mechanism of release.
Keywords :
drug delivery systems; polymer blends; bioerodible polyanhydrides; controlled drug delivery; erosion behavior; heterogeneous copolymers; in vitro release studies; monomer release kinetics; poly[1,6-bis(p-carboxy phenoxy)hexane-cosebacic anhydride]; release mechanism; tailored microstructure; thermodynamic partitioning; Amorphous materials; Atomic force microscopy; Control systems; Crystal microstructure; Crystallization; Drug delivery; Kinetic theory; Polymers; Presence network agents; Thermal degradation;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136899
