Title :
Development of multilayered sintered microsphere coatings to create unique delivery profiles
Author :
Raiche, A.T. ; Puleo, D.A.
Author_Institution :
Center for Biomed. Eng., Kentucky Univ., Lexington, KY, USA
Abstract :
A cascade of endogenous growth factors plays a role in bone healing following fracture. Including growth factors with time-variant concentrations in tissue-implant sites may improve healing response and prosthesis fixation. Biodegradable polymer coatings can be used to deliver osteotropic biomolecules. By nonuniformly immobilizing growth factors in device coatings, time-variant release profiles can be created. Multilayered coatings were fabricated by pressure-sintering protein-loaded microspheres. Protein release was strongly dependent on polymer degradation. Significant increases in protein delivery from 6 to 16 days were accomplished by varying the thickness of protein-loaded layers and by using additional coating layers to vary pathlength.
Keywords :
biomedical materials; coatings; drug delivery systems; molecular biophysics; orthopaedics; polymers; prosthetics; sintering; 6 to 16 day; biodegradable polymer; biodegradable polymer coatings; bone fracture healing; device coatings; endogenous growth factors cascade; implant coatings; multilayered sintered microsphere coatings development; nonuniformly immobilizing growth factors; osteotropic biomolecules delivery; polymer degradation; pressure-sintering protein-loaded microspheres; protein release; protein-loaded layers thickness variation; unique delivery profiles; Biodegradable materials; Bones; Coatings; Degradation; Fluorescence; Implants; Kinetic theory; Molecular biophysics; Polymer films; Proteins;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136900
