Title :
Localized delivery of anti-heparanase for inhibition of restenosis
Author :
Myler, Heather A. ; Rice, Elizabeth ; West, Jennifer L.
Author_Institution :
Dept. of Bioeng., Houston Univ., TX, USA
Abstract :
We have used hydrogel systems to locally deliver a possible inhibitor of restenosis. This inhibitor is an antibody against the active site of platelet-derived heparanase. This enzyme is involved in the activation of basic fibroblast growth factor stored in the extracellular matrix following vascular injury. The antibody was found to inhibit bFGF release from the arterial wall and to decrease intimal thickening by 60% (n=7; p<0.00003).
Keywords :
biochemistry; blood vessels; cellular biophysics; drug delivery systems; proteins; active site; anti-heparanase localized delivery; antibody; arterial wall; bFGF release; basic fibroblast growth factor activation; enzyme; extracellular matrix; hydrogel systems; intimal thickening; localized drug delivery; pharmacological agents; platelet-derived heparanase; restenosis inhibition; vascular injury; wound healing processes; Biochemistry; Carotid arteries; Electrochemical machining; Extracellular; Fibroblasts; Inhibitors; Injuries; Proteins; Sliding mode control; Surgery;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136932
