Title :
Microsensors to characterize shear stress regulating inflammatory responses in the arterial bifurcations
Author :
Hsiai, Tzung K. ; Cho, Sung K. ; Ing, Michael ; Navab, Mohamad ; Reddy, Srinuvasa ; Ho, Chih M.
Author_Institution :
Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA
Abstract :
Endothelial cells (EC) are able to discriminate the distinct characteristics of shear stress, unidirectional vs. reversal flow, and subsequently, expressing gene promoting or attenuating cardiovascular diseases. Using micro electro mechanical systems (MEMS) sensors, comparable to an elongated EC, we report the first evidence linking real-time shear stress with EC inflammatory responses via monocyte chemoattractant protein-1(MCP-1) expression and monocyte/EC binding kinetics.
Keywords :
biochemistry; biological techniques; biomechanics; blood vessels; cardiovascular system; cellular biophysics; diseases; genetics; haemorheology; microsensors; proteins; pulsatile flow; stress measurement; MEMS sensors; arterial bifurcations; elongated endothelial cells; endothelial cells; gene attenuating cardiovascular diseases; gene promoting cardiovascular diseases; inflammatory responses; micro electro mechanical system sensors; microsensors; monocyte chemoattractant protein-1 expression; monocyte/EC binding kinetics; pulsatile flow patterns; real-time shear stress; reversal flow; shear stress; shear stress regulating inflammatory responses; unidirectional flow; Bifurcation; Cardiovascular diseases; Joining processes; Mechanical sensors; Mechanical systems; Micromechanical devices; Microsensors; Sensor phenomena and characterization; Sensor systems; Stress;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1137005
