Title :
Force history dependence of reverse-rates of P-selectin interacting with PSGL-1
Author :
Zhu, C. ; Marshall, B.T. ; McEver, R.P.
Author_Institution :
Sch. of Mech. Eng., Georgia Inst. of Technol., Atlanta, GA, USA
Abstract :
The rates of dissociation of P-selectin bonded with two forms of PSGL-1 and an antibody were characterized using an atomic force microscope. The reverse-rates were shown to depend not only on force but also on the history of force application.
Keywords :
adhesion; atomic force microscopy; cellular biophysics; haemorheology; proteins; P-selectin interacting with PSGL-1; antibody; atomic force microscope; blood vessel wall endothelium; cell adhesion; dissociation rates; force application history; immune system response; kinetic rates; leukocyte rolling; leukocyte tethering; mechanically stressful environment; receptor/ligand bond; transient interactions; Atomic force microscopy; Biochemistry; Biology; Biomedical engineering; Bonding forces; Force measurement; Histograms; History; Kinetic theory; Mechanical engineering;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1137012
