Title :
Compositional effects on albumin system properties
Author :
Overby, R.J. ; Feldman, D.S.
Author_Institution :
Dept. of Biomed. Eng., Alabama Univ., Birmingham, AL, USA
Abstract :
Previous studies have shown that tissue scaffold systems for wound healing enhancement can be created using albumin crosslinked with a functionalized polyethylene glycol. The overall properties of this scaffold system are dictated by compositional factors such as functional end chemistry and component ratio as well as environmental effects like pH. In this study, we investigated how changes in composition and environment will affect such system properties as swellability, cure time, and degradation in an effort to select the best scaffold system. Ultimately, scaffolds will be optimized for specific clinical applications.
Keywords :
biochemistry; biological tissues; biomedical materials; curing; pH; patient treatment; polymer gels; proteins; swelling; albumin hydrogels; albumin system properties; component ratio; compositional effects; compositional factors; crosslinked albumin; cure time; degradation; environmental effects; functional end chemistry; functionalized polyethylene glycol; pH; specific clinical applications; swellability; tissue scaffold systems; wound healing enhancement; Analysis of variance; Biomedical engineering; Chemistry; Degradation; Dermis; In vivo; Polyethylene; Polymers; Tissue engineering; Wounds;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1137086
