In-vitro synthesis of elastin sheets on crosslinked hyaluronan gels for tissue engineering of aortic valves

Author

Ramamurthi, A. ; Vesely, I.

Author_Institution

Dept. of Biomed. Eng., Cleveland Clinic Found., OH, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

854

Abstract

The complex three-layered structure of aortic valve cusps is organized from collagen, glycosaminoglycans, and elastin. Our approach to tissue engineering the aortic valve is to fabricate a functional composite tissue from each layer grown separately in vitro. This paper summarizes our efforts to fabricate the viscoelastic spongiosa, and the elastin-rich ventricularis.

Keywords

biomedical materials; cardiovascular system; gels; proteins; viscoelasticity; aortic valve cusps; bioprosthetic valves; crosslinked hyaluronan gels; elastin sheets; elastin-rich ventricularis; functional composite tissue; in-vitro synthesis; mechanical damage; tissue calcification; tissue engineering; tissue layers growth; viscoelastic spongiosa fabrication; Biological materials; Cardiology; Elasticity; Heart valves; In vitro; Medical treatment; Surface morphology; Tellurium; Tissue engineering; Viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1137110

Filename

1137110