Osteoblast growth and functions in porous degradable synthetic matrices for bone repair: a preliminary study

Large bone defects can be repaired only when the bone substitute is available in proper amount. Engineered bone seems a promising approach, but a number of variables have to be set before any conclusion is drawn. Poly-caprolactone-based polymers, with different porosity and -HA or +HA particles, have been tested in vitro using osteoblast-like Saos2 cells. Preliminary results show that the polymers, though degrading in the medium, have a positive interaction with cells, as they support cell growth and functions.