Osteoblast growth and functions in porous degradable synthetic matrices for bone repair: a preliminary study

Author

Ciapetti, G. ; Baldini, N. ; Savarino, L. ; Pagani, S. ; Martini, D. ; Ambrosio, Leonardo ; Giunti, A.

Author_Institution

Laboratorio di Fisiopatologia, Bologna Univ., Italy

fYear

2002

fDate

2002

Firstpage

48

Lastpage

49

Abstract

Large bone defects can be repaired only when the bone substitute is available in proper amount. Engineered bone seems a promising approach, but a number of variables have to be set before any conclusion is drawn. Poly-caprolactone-based polymers, with different porosity and -HA or +HA particles, have been tested in vitro using osteoblast-like Saos2 cells. Preliminary results show that the polymers, though degrading in the medium, have a positive interaction with cells, as they support cell growth and functions.

Keywords

biomedical materials; cellular biophysics; orthopaedics; polymers; porous materials; +HA particles; -HA particles; biodegradation; bone repair; cell growth support; in vitro tests; osteoblast functions; osteoblast-like Saos2 cells; osteoblasts; poly-caprolactone-based polymers; porous degradable synthetic matrices; Biodegradable materials; Biodegradation; Bones; In vitro; In vivo; Laboratories; Polymers; Scanning electron microscopy; Testing; Thermal degradation;

fLanguage

English

Publisher

ieee

Conference_Titel

Molecular, Cellular and Tissue Engineering, 2002. Proceedings of the IEEE-EMBS Special Topic Conference on

Print_ISBN

0-7803-7557-2

Type

conf

DOI

10.1109/MCTE.2002.1174997

Filename

1174997