Title :
Modelling hydrophobicity to identify secondary structure signals in globular proteins
Author :
Sacile, R. ; Ruggiero, C.
Author_Institution :
Dept. of Commun., Comput. & Syst. Sci., Univ. of Genova, Italy
Abstract :
In globular proteins the hydrophobic effect is a well-known phenomenon that is more and more investigated in relation with protein folding. The Discrete Fourier Transform of the hydrophobic profile of the primary structure, resulting in the so-called amphipatic plots, allow to identify some regular structures. We present a modelling method, which aims to improve both the user-friendliness and the quality of the representation of the amphipatic plots.
Keywords :
discrete Fourier transforms; molecular biophysics; molecular configurations; physiological models; proteins; amphipatic plots representation; globular proteins; hydrophobicity modelling; modelling method; primary structure; protein folding; regular structures identification; representation quality improvement; user-friendliness improvement; Biomembranes; Discrete Fourier transforms; Frequency; Pattern analysis; Pattern matching; Peptides; Position measurement; Proteins; Sequences; Signal processing;
Conference_Titel :
Molecular, Cellular and Tissue Engineering, 2002. Proceedings of the IEEE-EMBS Special Topic Conference on
Print_ISBN :
0-7803-7557-2
DOI :
10.1109/MCTE.2002.1175040
