• DocumentCode
    389644
  • Title

    Near optimal solutions navigator

  • Author

    Smoot, Michael E. ; Pearson, William R. ; Guerlain, Stephanie A.

  • Author_Institution
    Dept. of Syst. & Inf. Eng., Virginia Univ., Charlottesville, VA, USA
  • Volume
    5
  • fYear
    2002
  • fDate
    6-9 Oct. 2002
  • Abstract
    Sometimes, "optimal" solutions fail to meet operational objectives. Nevertheless, we expect that the operationally optimal solution lies near the algorithmically optimal solution. Various algorithms can be used to generate near optimal, alternative solutions, but there are significant challenges In displaying the multiple solutions to the decision maker, and to provide the additional Information necessary for the decision maker to understand the differences between solutions and make an Informed decision. We show that in the bioinformatics domain of aligning protein/DNA sequences, a small set of near-optimal alignments are closer to the biologically known alignment than the optimal solution returned by the sequence alignment algorithms. Thus, we have developed a system for generating, viewing and comparing solutions among a set of near-optimal alternatives.
  • Keywords
    DNA; biology computing; decision support systems; molecular biophysics; proteins; sequences; DNA sequence alignment; algorithmically optimal solution; bioinformatics; decision support systems; near optimal solutions navigator; near-optimal alignments; operational objectives; operationally optimal solution; protein sequence alignment; Automation; DNA; Databases; Displays; Humans; Navigation; Proteins; Sequences; Systems engineering and theory; Visualization;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Systems, Man and Cybernetics, 2002 IEEE International Conference on
  • ISSN
    1062-922X
  • Print_ISBN
    0-7803-7437-1
  • Type

    conf

  • DOI
    10.1109/ICSMC.2002.1176437
  • Filename
    1176437