DocumentCode
399961
Title
Real-time two-photon fluorescence microscopy of blood flow dynamics following photothrombotic stroke in rat neocortex
Author
Schaffer, Chris B. ; Ebner, Ford F. ; Nishimura, Nozomi ; Friedman, Beth ; Tsai, Phibert S. ; Schroeder, Lee F. ; Lyden, Patrick D. ; Kleinfeld, David
Author_Institution
Dept. of Phys., California Univ., La Jolla, CA, USA
Volume
1
fYear
2003
fDate
27-28 Oct. 2003
Firstpage
307
Abstract
We use two-photon microscopy to observe changes in blood flow after localized photothrombotic clotting of individual blood vessels in rat neocortex. We find that flow reverses direction downstream from clotted arterioles, thereby maintaining tissue perfusion.
Keywords
bio-optics; biomedical optical imaging; blood flow measurement; blood vessels; brain; diseases; fluorescence; haemorheology; optical microscopy; two-photon processes; blood flow; blood vessels; clotted arterioles; photothrombotic clotting; photothrombotic stroke; rat neocortex; real-time fluorescence microscopy; tissue perfusion; two-photon fluorescence microscopy; Animals; Blood flow; Blood vessels; Coagulation; Fluorescence; Ischemic pain; Microscopy; Physics; Rats; Red blood cells;
fLanguage
English
Publisher
ieee
Conference_Titel
Lasers and Electro-Optics Society, 2003. LEOS 2003. The 16th Annual Meeting of the IEEE
ISSN
1092-8081
Print_ISBN
0-7803-7888-1
Type
conf
DOI
10.1109/LEOS.2003.1251760
Filename
1251760
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