Modeling of electro-mechanics of human cardiac myocytes: parameterization with numerical minimization techniques

Knowledge of cardiac electro-mechanical phenomena can be achieved by mathematical modeling and numerical simulation. Topic of the work is the assembly and parameterization of an electro-mechanical model of human cardiac myocytes. The model integrates an electrophysiological and a tension development model. This integration and additional adaptation to studies of human myocardium necessitated re-parameterization of several components, which was performed applying different numerical optimization techniques. Results and characteristics of the parameterization are illustrated by numerical experiments. Simulations with the electro-mechanical model show characteristic shapes of the courses of transmembrane voltage, concentration of intracellular calcium, and developed tension.