DocumentCode :
42156
Title :
Toward Integrated Molecular Diagnostic System ( i MDx): Principles and Applications
Author :
Seung-min Park ; Sabour, Andrew F. ; Jun Ho Son ; Sang Hun Lee ; Lee, L.P.
Author_Institution :
Dept. of Bioeng., Univ. of California, Berkeley, Berkeley, CA, USA
Volume :
61
Issue :
5
fYear :
2014
fDate :
May-14
Firstpage :
1506
Lastpage :
1521
Abstract :
Integrated molecular diagnostic systems (iMDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addressed to discuss the practicality for future patient care. We envision that microfluidic systems hold the potential to breakthrough the number of problems brought into the field of medical diagnosis today.
Keywords :
bioMEMS; medical signal processing; microfluidics; molecular biophysics; patient care; patient diagnosis; clinical field; filtration; future patient care; iMDx; integrated molecular diagnostic systems; medical diagnosis; microfluidic systems; point-of-care devices; preservation; sample amplification; sample extraction; signal transduction; total device integration; Biomembranes; Blood; DNA; Microfluidics; Molecular biophysics; Plasmas; Proteins; Diagnostics; integration; microfluidics; point-of-care (POC);
fLanguage :
English
Journal_Title :
Biomedical Engineering, IEEE Transactions on
Publisher :
ieee
ISSN :
0018-9294
Type :
jour
DOI :
10.1109/TBME.2014.2309119
Filename :
6775268
Link To Document :
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