Saccadic parameters for early identification of neuronopathic Gaucher´s disease

For a successful treatment of the neurological form of Gaucher´s disease ,an early identification is necessary. Often an alteration of the horizontal saccadic eye movements constitutes the first sign of a central nervous system involvement. In order to obtain an early identification of the neuronopathic forms of the disease, often masked by the use of the enzyme replacement therapy, the classical saccadic characteristics (latency, amplitude vs. duration and amplitude vs. peak velocity relationships) are not usable. This work studies if some other parameters (mean velocity/peak velocity, kurtosis, skewness, asymmetry), are able to describe the saccadic velocity profiles, could be considered to build an expert system able to reach the aim.