Title :
Physiologically-based minimal model of agitation-sedation dynamics
Author :
Rudge, A.D. ; Chase, J.G. ; Shaw, G.M. ; Lee, D.
Author_Institution :
Dept. of Mechanical Eng., Canterbury Univ., Christchurch, New Zealand
Abstract :
Agitation-sedation cycling in critically ill patients, characterized by oscillations between states of agitation and over-sedation, damages patient health and increases length of stay and cost. The model presented captures the essential dynamics of the agitation-sedation system, is physiologically representative, and is validated by accurately simulating patient response for 37 critical care patients. The model provides a platform to develop and test controllers that offer the potential of improved agitation management.
Keywords :
patient treatment; physiological models; agitation-sedation dynamics; critical care patients; improved agitation management; patient health; physiologically-based minimal model; Costs; Drugs; Hospitals; Mathematics; Mechanical engineering; Medical treatment; Nonlinear dynamical systems; Protocols; Statistics; Testing; Agitation; Dynamic modeling; Non-linear dynamics; Physiological models; Sedation;
Conference_Titel :
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-8439-3
DOI :
10.1109/IEMBS.2004.1403273
