Title :
Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models
Author :
Plawecki, M.H. ; Decarlo, R.A. ; Ramchandani, V.A. ; O´Connor, S.
Author_Institution :
Dept. of Biomedical Eng., Purdue Univ., West Lafayette, IN, USA
Abstract :
A procedure for estimating the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course using a PBPK model is described. Model parameter values are predicted from linear relationships to readily measurable physical characteristics or morphometrics. An algorithm to optimize this transformation, based upon recorded clinical experimental data, is provided. A substantial improvement in all error statistics, in relation to the original transform was obtained.
Keywords :
drugs; estimation theory; physiological models; alcohol infusion profile; ethanol infusion profile estimation; morphometrics; physiologically-based pharmacokinetic models; specific breath alcohol concentration time course; Absorption; Alcoholic beverages; Alcoholism; Biomedical engineering; Biomedical measurements; Clamps; Drugs; Ethanol; History; Physiology; alcohol; breath alcohol concentration time course; least squares approximation; morphometrics; optimization; parameter identification; pharmacokinetics; physiologically-based pharmacokinetic model;
Conference_Titel :
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-8439-3
DOI :
10.1109/IEMBS.2004.1403274
