Title :
Drug dosage level design to maximize the benefits of therapy
Author :
Jeffrey, A.M. ; Xia, Xiang-Gen ; Craig, I.K.
Abstract :
Currently, antiretroviral agents are administered in a fixed dosage style. Sampling is usually done before therapy is initiated in order to decide when therapy will be initiated, then again 2-8 weeks after the initiation of therapy to assess the initial effect of therapy. The paper presents a model predictive control approach to therapy dosage scheduling when blood samples are taken at a parameter dependent fixed interval
Keywords :
biocontrol; control system analysis; control system synthesis; drug delivery systems; optimisation; predictive control; scheduling; antiretroviral agents; blood samples; drug dosage level design; fixed dosage; model predictive control; parameter dependent fixed interval; therapy dosage scheduling; Blood; Drugs; Human immunodeficiency virus; Immune system; Mathematical model; Medical treatment; Optimal control; Predictive control; Predictive models; Sampling methods;
Conference_Titel :
AFRICON, 2004. 7th AFRICON Conference in Africa
Conference_Location :
Gaborone
Print_ISBN :
0-7803-8605-1
DOI :
10.1109/AFRICON.2004.1406718
