Title :
THz-biology: studying protein dynamics in solution
Author :
Havenith, M. ; Heugen, U. ; Bergner, A. ; Ebbinghaus, S. ; Bründermann, E. ; Larios, E. ; Leitner, D.M. ; Gruebele, M.
Author_Institution :
Lehrstuhl fur Physikalische Chemie II, Ruhr-Univ., Bochum, Germany
fDate :
27 Sept.-1 Oct. 2004
Abstract :
THz spectrometer to measure absorption spectra of solvated proteins is developed. The radiation source is a p-type germanium laser which delivers output powers of several watts in the THz regime (from 1-4 THz). Experimental results for different mutants of ubiquitin and λ-repressor which serve as prototype systems is presented and compared with theoretical studies using molecular dynamics simulation.
Keywords :
absorption coefficients; molecular dynamics method; proteins; submillimetre wave spectra; 1 to 4 THz; THz spectrometer; absorption coefficient; absorption spectra; lambda repressor; molecular dynamics simulation; p-type germanium laser; protein dynamics; prototype systems; radiation source; ubiquitin; Absorption; Amino acids; Chemical lasers; Frequency; Germanium; Gratings; Power lasers; Protein engineering; Spectroscopy; Temperature;
Conference_Titel :
Infrared and Millimeter Waves, 2004 and 12th International Conference on Terahertz Electronics, 2004. Conference Digest of the 2004 Joint 29th International Conference on
Print_ISBN :
0-7803-8490-3
DOI :
10.1109/ICIMW.2004.1422300
