Title :
16-channel wide-range VLSI potentiostat array
Author :
Stanacevic, Milutin ; Murari, Kurtikeya ; Cauwenberghs, Gert ; Thako, Nitish
Author_Institution :
Dept. of Electr. & Comput. Eng., Johns Hopkins Univ., Baltimore, MD, USA
Abstract :
A 16-channel current-measuring VLSI sensor array system for electrochemical detection of electroactive neurotransmitters like dopamine and nitric-oxide is presented. The designed ADC architecture is first-order single bit delta-sigma modulator with programmable oversampling ratio. The modulation of feedback duty-cycle in modulator design enables choice of current range in accordance to magnitude and time constant of signal leading to current range that spans over six orders of magnitude and sensitivity up to picoamperes at hundred millisecond conversion time with power consumption of 300 μW. A 3 mm × 3 mm chip in 0.5 μm CMOS technology is used for real-time multi-channel acquisition of neurotransmitter concentration.
Keywords :
CMOS integrated circuits; VLSI; biochemistry; biomedical equipment; delta-sigma modulation; electrochemical sensors; feedback; molecular biophysics; neurophysiology; 3 mm; 300 muW; CMOS; current-measuring VLSI sensor; dopamine; electroactive neurotransmitters; electrochemical detection; feedback duty-cycle; first-order single bit delta-sigma modulator; neurotransmitter concentration; nitric-oxide; programmable oversampling ratio; real-time multi-channel acquisition; wide-range VLSI potentiostat array; CMOS technology; Delta modulation; Energy consumption; Modulation coding; Neurofeedback; Neurotransmitters; Sensor arrays; Sensor systems; Signal design; Very large scale integration;
Conference_Titel :
Biomedical Circuits and Systems, 2004 IEEE International Workshop on
Print_ISBN :
0-7803-8665-5
DOI :
10.1109/BIOCAS.2004.1454176
