Title :
A "mouse-sized" gamma camera for biological imaging
Author :
Bradley, E.L. ; Cella, J. ; Majewski, S. ; Popov, V. ; Qian, J. ; Saha, M.S. ; Smith, M.F. ; Weisenberger, A.G. ; Welsh, R.E.
Author_Institution :
Dept. of Biol., Coll. of William & Mary, Williamsburg, VA
Abstract :
A compact detector, sized particularly for imaging a mouse, is described. The active area of the detector is approximately 48 mmtimes96 mm. Two flat-panel Hamamatsu H8500 position sensitive photomultiplier tubes (PSPMT) are coupled to a pixellated NaI(Tl) scintillator which views the animal through a copper-beryllium (CuBe) parallel-hole collimator. Because the PSPMTs have insensitive areas at their edges, particular care has been given to bridging the gap where the two tubes join so as to maintain uniform response across the entire rectangular area of the detector. The system described has been developed to optimize both sensitivity and resolution for in vivo imaging of small animals injected with iodinated compounds. We demonstrate an in vivo application of this detector by imaging a mouse injected with 10 muCi of 125I
Keywords :
collimators; gamma-ray apparatus; photomultipliers; position sensitive particle detectors; radioisotope imaging; solid scintillation detectors; 48 mm; 96 mm; 125I; CuBe; I; PSPMT; biological imaging; compact detector; copper-beryllium parallel-hole collimator; flat-panel Hamamatsu H8500 position sensitive photomultiplier tubes; in vivo imaging; iodinated compounds; mouse-sized gamma camera; pixellated NaI(Tl) scintillator; small animals; Animals; Cameras; Collimators; Detectors; Image edge detection; Image resolution; In vivo; Mice; Optical imaging; Photomultipliers;
Conference_Titel :
Nuclear Science Symposium Conference Record, 2004 IEEE
Conference_Location :
Rome
Print_ISBN :
0-7803-8700-7
Electronic_ISBN :
1082-3654
DOI :
10.1109/NSSMIC.2004.1466302
