Title :
Role of presynaptic reuptake on dopamine modulation of cortico-striatal activity in TD learning
Author :
Wanjerkhede, Shesharao M. ; Bapi, Raju S.
Author_Institution :
Dept. of Comput. & Inf. Sci., Hyderabad Univ., India
fDate :
July 31 2005-Aug. 4 2005
Abstract :
It has been shown that midbrain dopamine neurons and the dopamine neuronal activity in the striatum mimic reward prediction error signal of the temporal difference learning (TDL) paradigm. James Houk proposed a theoretical model to explain the cellular basis of this dopamine activity. Our goal is to verify this model with simulations in GENESIS and CHEMESIS. This paper reports preliminary results from the simulations of this intracellular signaling scheme. The main result reported here is the influence of presynaptic reuptake on dopamine activity at the cortico-striatal synapse. It appears that the reuptake affects the rate of formation of D1_DA receptor complex that in turn would have a bearing on the timing mechanisms operating in TDL.
Keywords :
biophysics; brain; learning (artificial intelligence); temporal reasoning; cortico-striatal activity; dopamine modulation; intracellular signaling scheme; midbrain dopamine neurons; prediction error signal; presynaptic reuptake; temporal difference learning; Animals; Basal ganglia; Computer errors; Machine learning; Machine learning algorithms; Neurons; Neurotransmitters; Predictive models; Timing; Wheels;
Conference_Titel :
Neural Networks, 2005. IJCNN '05. Proceedings. 2005 IEEE International Joint Conference on
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-9048-2
DOI :
10.1109/IJCNN.2005.1556232
