Title :
Microarray Analysis of Ovarian Cancer
Author :
Huang, G. Steven ; Hung, Yao-Ching ; Chen, Ann ; Hong, Meng-Yen
Author_Institution :
Inst. of Nanotechnology, Nat. Chiao Tung Univ., Hsinchu
Abstract :
Microarray experiments were performed to normal ovaries, benign ovarian tumor and stage I and III of ovarian cancer. By treating benign ovarian tumor as pre-cancerous stage and comparing to later stages of ovarian cancer we identified 46 genes overly expressed in early-staged cancer. We also identified over-expressed genes at all stages of ovarian tumor/cancer. The over-expressed genes might be alternative candidates for developing early diagnostic markers. JUN and nuclear receptor subfamily genes were repeatedly identified in the group of down-regulated genes indicating their important regulatory roles in the oncogenesis of ovary
Keywords :
cancer; cellular biophysics; genetics; medical computing; pattern classification; tumours; diagnostic markers; down-regulated genes; microarray analysis; nuclear receptor subfamily genes; ovarian cancer; over-expressed genes; Benign tumors; Bioinformatics; Cancer detection; Gene expression; Genomics; Hospitals; Medical diagnostic imaging; Nanotechnology; Neoplasms; Pathology; Microarray; early diagnostic marker; gene expression; ovarian cancer;
Conference_Titel :
Systems, Man and Cybernetics, 2005 IEEE International Conference on
Conference_Location :
Waikoloa, HI
Print_ISBN :
0-7803-9298-1
DOI :
10.1109/ICSMC.2005.1571282
