Molecular imaging of cancer cells using plasmon-resonant-enhanced third-harmonic-generation microscopy with silver nanoparticles

Author

Tai, Shih-Peng ; Chu, Shi-Wei ; Tsai, Tsung-Han ; Chen, Szu-Yu ; Shi, Xuan-Yu ; Chang, Chien-Huei ; Wu, Yana ; Shieh, Dar-Bin ; Chen, Lung-Jin ; Prasad, Muppa Ramakrishna ; Lin, Kuan-Jiuh ; Sun, Chi-Kuang

Author_Institution

Graduate Inst. of Electro-Opt. Eng., Nat. Taiwan Univ., Taiwan

Volume

2

fYear

2005

fDate

22-27 May 2005

Firstpage

1521

Abstract

We demonstrate molecular-specific third-harmonic-generation microscopy in cultured oral squamous cell carcinoma lines by using silver nano-particles as contrast agent. Through surface plasmon resonance enhancement, cancer cells are clearly identified with their molecular signature.

Keywords

biomedical optical imaging; cancer; cellular biophysics; molecular biophysics; nanoparticles; optical harmonic generation; optical microscopy; silver; surface plasmon resonance; tumours; Ag; cancer cell imaging; contrast agent; cultured oral squamous cell carcinoma; molecular imaging; molecular signature; molecular-specific third-harmonic-generation microscopy; plasmon-resonant-enhanced third-harmonic-generation microscopy; silver nanoparticles; surface plasmon resonance enhancement; Biomedical optical imaging; Cancer; Molecular imaging; Nanoparticles; Nonlinear optics; Optical imaging; Optical microscopy; Plasmons; Resonance; Silver;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics, 2005. (CLEO). Conference on

Print_ISBN

1-55752-795-4

Type

conf

DOI

10.1109/CLEO.2005.202179

Filename

1573245