Title :
The Effect of UV Irradiation on the Binding of Anticancer Drug Doxorubicin to DNA in the Presence of TiO/sub 2/ Nanoparticles Binding Drug to DNA
Author :
Song, Min ; Wang, Xuemei
Author_Institution :
Southeast Univ, Nanjing
Abstract :
The considerable effect of titanium dioxide (TiO2) nanoparticles and UV irradiation on the biomolecular binding behavior of anticancer drug doxorubicin has been studied by using electrochemical methods. Our observations demonstrate that the combination of nano TiO2 and UV irradiation could facilitate the respective DNA binding affinity of anticancer agent and significantly enhance the detection sensitivity for the relative biomolecular recognition process.
Keywords :
DNA; biochemistry; biological effects of ultraviolet radiation; biomolecular effects of radiation; drugs; electrochemical analysis; nanoparticles; pattern recognition; titanium compounds; DNA binding affinity; TiO2; UV irradiation; anticancer drug doxorubicin; biomolecular binding behavior; biomolecular recognition process; electrochemical method; titanium dioxide nanoparticles;
Conference_Titel :
Biomedical and Pharmaceutical Engineering, 2006. ICBPE 2006. International Conference on
Conference_Location :
Singapore
Print_ISBN :
978-981-05-79
Electronic_ISBN :
81-904262-1-4
