Title :
Control in a family of Boolean networks
Author :
Choudhary, Ashish ; Datta, Aniruddha ; Bittner, Michael L. ; Dougherty, Edward R.
Author_Institution :
Texas A & M Univ., College Station, TX
Abstract :
Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied in the framework of a probabilistic Boolean network (PBN), which is obtained by joining several Boolean networks (BN) using a probabilistic structure. In this work we treat a case in which we lack this governing probability structure for Boolean network selection, so we simply have a family of Boolean networks, where these networks possess a common attractor structure matching the data states, which are assumed to arise from sampling the steady state of the real biological network.
Keywords :
Boolean functions; biology; probability; gene regulatory network; probabilistic Boolean network; probability structure; Bioinformatics; Computer networks; Costs; Diseases; Genomics; Intelligent networks; Inverse problems; Malignant tumors; Metastasis; Steady-state;
Conference_Titel :
Genomic Signal Processing and Statistics, 2006. GENSIPS '06. IEEE International Workshop on
Conference_Location :
College Station, TX
Print_ISBN :
1-4244-0384-7
Electronic_ISBN :
1-4244-0385-5
DOI :
10.1109/GENSIPS.2006.353133