Kinetic modeling of PET data and FDG continuous infusion in rat tumors simultaneously treated with PDT

Author

Bentourkia, M´hamed ; Boubacar, P. ; Berard, V. ; van Lier, J.E. ; Lecomte, Roger

Author_Institution

Univ. de Sherbrooke, Sherbrooke

Volume

5

fYear

2007

fDate

Oct. 26 2007-Nov. 3 2007

Firstpage

4035

Lastpage

4039

Abstract

The aim of this work was to assess by kinetic modeling the effects of the photodynamic therapy (PDT) of cancer in two mammary adenocarcinoma tumors implanted in the axillary areas of rats. One tumor served as control while the other was treated with red light 24 hours after administration of two types of photosensitizers: AlPcS₄ and ZnPcS₂. PET scans were carried on, with a continuous infusion of fluorodeoxyglucose (FDG), during 2 hours including the 30 min duration of the illumination of the tumor. The usual FDG kinetic model was modified to include the effects of the treatment. Since the blood supply to the tumors was affected by the illumination during the PET scans, the input curve was derived from factor analysis. A study of the FDG kinetic compartment model and rate constants is presented for both AlPcS₄ and ZnPcS₂

Keywords

biological organs; blood; cancer; photodynamic therapy; positron emission tomography; tumours; AlPcS₄ photosensitizers; FDG kinetic compartment model; PDT treatment; PET data kinetic modeling; PET scanning; ZnPcS₂ photosensitizers; blood supply; fluorodeoxyglucose continuous infusion; mammary adenocarcinoma tumors; photodynamic therapy; rat axillary areas; time 2 hr; time 24 hr; time 30 min; tumor illumination; Blood; Cancer; Kinetic theory; Lighting; Medical treatment; Neoplasms; Nuclear and plasma sciences; Positron emission tomography; Rats; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2007. NSS '07. IEEE

Conference_Location

Honolulu, HI

ISSN

1095-7863

Print_ISBN

978-1-4244-0922-8

Electronic_ISBN

1095-7863

Type

conf

DOI

10.1109/NSSMIC.2007.4436998

Filename

4436998