• DocumentCode
    471354
  • Title

    Simulation of biochemical networks - Cellular networks as dynamic control systems

  • Author

    Sauro, Herbert M.

  • Author_Institution
    Keck Graduate Inst., Claremont, CA
  • fYear
    2006
  • fDate
    Aug. 30 2006-Sept. 3 2006
  • Firstpage
    44
  • Lastpage
    50
  • Abstract
    It has been appreciated for at least a hundred years that biological organisms contain control systems that enable them to adapt to a changing environment and adjust their internal systems when they need to proliferate. Even so, we have little understanding of the role that many of the control systems play. It´s only in recent years that mainstream science has begun to study biological systems qualitatively and to look specifically at dynamical responses. As a result it might be possible that future cancer therapies will operate by manipulating the control systems that have gone awry during uncontrolled proliferation. This is a long term goal because it would require a mind shift in the way some biologists approach such problems. In this short paper the author describes some of the main control elements found in biological systems and illustrate their use in biological networks. In addition the author discuss some of the strategies that one can use to build computational models
  • Keywords
    biochemistry; cancer; cellular biophysics; medical computing; nonlinear control systems; nonlinear dynamical systems; biochemical networks; biological organisms; biological systems; cancer therapies; cellular networks; computational models; dynamic control systems; Biological control systems; Biological system modeling; Biological systems; Biology computing; Cancer; Computational modeling; Control system synthesis; Control systems; Land mobile radio cellular systems; Medical treatment;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
  • Conference_Location
    New York, NY
  • ISSN
    1557-170X
  • Print_ISBN
    1-4244-0032-5
  • Electronic_ISBN
    1557-170X
  • Type

    conf

  • DOI
    10.1109/IEMBS.2006.259755
  • Filename
    4461680