Title :
Mixed Meal Simulation Model of Glucose-Insulin System
Author :
Man, Chiara Dalla ; Rizza, Robert A. ; Cobelli, Claudio
Author_Institution :
Dept. of Inf. Eng., Padova Univ.
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
A simulation model of the glucose-insulin system in the postprandial state can be useful for studying the pathophysiology of diabetes. Here we present a new simulation model which describes the physiological events which occur after a meal, by employing the quantitative knowledge which has become available in recent years. Model parameters were set to fit data of 204 normal subjects which underwent a triple tracer meal protocol which provided quasi model-independent estimates of major glucose and insulin fluxes. Model results are shown in describing normal daily life (breakfast, lunch, dinner) both in normal and pathophysiological situations. The potential of the model for studying type 1 diabetes is illustrated by simulating both open- and closed-loop insulin infusion strategies
Keywords :
biochemistry; diseases; physiological models; closed-loop insulin infusion strategy; diabetes; glucose-insulin system; insulin fluxes; mixed meal simulation model; normal subjects; open-loop insulin infusion strategy; pathophysiological subjects; pathophysiology; physiological events; postprandial state; quasi model-independent glucose estimation; triple tracer meal protocol; Absorption; Biochemistry; Cities and towns; Diabetes; Insulin; Kinetic theory; Plasma measurements; Plasma simulation; Protocols; Sugar;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.260810
