DocumentCode :
471478
Title :
Arterial pulse wave velocity in coronary arteries
Author :
Aguado-Sierra, J. ; Parker, K.H. ; Davies, J.E. ; Francis, D. ; Hughes, A.D. ; Mayer, Jonas
Author_Institution :
Dept. of Bioeng., Imperial Coll. London
fYear :
2006
fDate :
Aug. 30 2006-Sept. 3 2006
Firstpage :
867
Lastpage :
870
Abstract :
Pulse wave velocity is related to arterial stiffness. Pulse wave velocity changes with age and disease and is a useful indicator of cardiovascular disease. Different methods are used for evaluating pulse wave velocity in systemic vessels, but none is applicable to coronary arteries. In this study we first compare values of wave speed (c) calculated from measurements of pressure (P) and velocity (U) using different analytical methods: PU-loop, beta stiffness parameter, characteristic impedance, foot-to-foot method, and the sum of squares (Sigma2), a novel way of calculating the wave speed (calculated from the square root of the sum of the ratio of the dP2 and dU2 over a complete cardiac cycle). Results from human measurements using Doppler ultrasound on carotid arteries show good correlation between the PU-loop method, beta stiffness parameter and Sigma2. Characteristic impedance calculations show the greatest variation of all methods. The Sigma2 method was further assessed in vitro for use in coronary vessels. Pressure and velocity measurements were obtained from human coronary arteries following angiographic studies. The measurements were made invasively by co-locating two wires with pressure and velocity transducers. Pressure and velocity data in the left anterior descending, circumflex, left main stem and right coronary arteries were acquired simultaneously along with the ECG signal. Wave speed was calculated using Sigma2. Wave intensity analysis was used to determine forward and backward traveling waves at different times in different locations, for which wave speed, approximate distance and timings between waves need to be known
Keywords :
Doppler measurement; angiocardiography; approximation theory; biomechanics; biomedical ultrasonics; blood pressure measurement; blood vessels; cardiovascular system; electrocardiography; ultrasonic measurement; velocity measurement; Doppler ultrasound; ECG signal; angiographic studies; arterial pulse wave velocity; backward traveling waves; beta stiffness parameter; cardiovascular disease; carotid arteries; characteristic impedance; circumflex arteries; foot-to-foot method; forward traveling waves; human coronary arterial stiffness; in vitro study; left anterior descending arteries; left main stem arteries; pressure measurement; right coronary arteries; sum-of-squares method; systemic vessels; velocity measurement; Anthropometry; Arteries; Cardiac disease; Cardiovascular diseases; Humans; Impedance measurement; Pressure measurement; Ultrasonic imaging; Ultrasonic variables measurement; Velocity measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
ISSN :
1557-170X
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2006.259375
Filename :
4461889
Link To Document :
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