Pre-Ictal Entropy Analysis of Microwire Data from an Animal Model of Limbic Epilepsy

Author

Mishra, Mitushi ; Jones, Britta ; Simonotto, Jennifer D. ; Furman, Michael D. ; Norman, Wendy M. ; Liu, Zhao ; DeMarse, Thomas B. ; Carney, Paul R. ; Ditto, William L.

Author_Institution

Dept. of Biomed. Eng., Florida Univ., Gainesville, FL

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

1605

Lastpage

1607

Abstract

Epilepsy is a common neurological disorder that can have damaging effects in the brain including over 50% loss of neuronal activity in the hippocampal regions of the CA1 and CA3. The pre-ictal period was studied in an animal model of limbic epilepsy using Shannon entropy and correlation analysis. The primary aim was to uncover underlying relative changes in signals between the Dentate Gyrus and CA1 areas of the bilateral hippocampus. Preliminary entropy analysis results included dynamical changes between channels in the Dentate Gyrus and channels in the CA1 region at and around the time of the seizure

Keywords

bioelectric phenomena; biomedical electrodes; biomedical measurement; brain; correlation theory; diseases; entropy; microelectrodes; neurophysiology; Dentate Gyrus; Shannon entropy; animal model; bilateral hippocampus; brain; correlation analysis; limbic epilepsy; microwire electrode data; neurological disorder; neuronal activity; pre-ictal period; Animals; Brain modeling; Data analysis; Electrodes; Entropy; Epilepsy; Hippocampus; Magnetic resonance imaging; Neurons; USA Councils; Shannon entropy; latent period; limbic epilepsy;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.259685

Filename

4462074