Characterization of Mouse Brain and Its Development using Diffusion Tensor Imaging and Computational Techniques

Author

Zhang, Jiangyang ; Richards, Linda J. ; Miller, Michael I. ; Yarowsky, Paul ; Van Zijl, Peter ; Mori, Susumu

Author_Institution

Dept. of Radiol., Johns Hopkins Univ. Sch. of Med., Baltimore, MD

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

2252

Lastpage

2255

Abstract

Diffusion tensor magnetic resonance imaging (DTI) was used to study mouse brain development from early embryonic stage to adult. DTI provides necessary resolution and superb white matter and gray matter contrast in embryonic and neonatal brains for characterization of morphological changes during mouse brain development. A database and a digital atlas of developing mouse brains based on our DTI results are being constructed. To characterize the spatial and temporal patterns of mouse brain development, we applied landmark based computational techniques to analyze the database

Keywords

biomedical MRI; brain; neurophysiology; computational techniques; database analysis; diffusion tensor MR imaging; digital atlas; early embryonic stage; embryonic brain; gray matter contrast; image resolution; magnetic resonance imaging; morphological change characterization; mouse brain development; neonatal brains; white matter contrast; Animals; Biomedical imaging; Biomedical measurements; Diffusion tensor imaging; Embryo; Humans; Magnetic resonance imaging; Mice; Radiology; Tensile stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.259388

Filename

4462240