Title :
Characterization of Mouse Brain and Its Development using Diffusion Tensor Imaging and Computational Techniques
Author :
Zhang, Jiangyang ; Richards, Linda J. ; Miller, Michael I. ; Yarowsky, Paul ; Van Zijl, Peter ; Mori, Susumu
Author_Institution :
Dept. of Radiol., Johns Hopkins Univ. Sch. of Med., Baltimore, MD
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
Diffusion tensor magnetic resonance imaging (DTI) was used to study mouse brain development from early embryonic stage to adult. DTI provides necessary resolution and superb white matter and gray matter contrast in embryonic and neonatal brains for characterization of morphological changes during mouse brain development. A database and a digital atlas of developing mouse brains based on our DTI results are being constructed. To characterize the spatial and temporal patterns of mouse brain development, we applied landmark based computational techniques to analyze the database
Keywords :
biomedical MRI; brain; neurophysiology; computational techniques; database analysis; diffusion tensor MR imaging; digital atlas; early embryonic stage; embryonic brain; gray matter contrast; image resolution; magnetic resonance imaging; morphological change characterization; mouse brain development; neonatal brains; white matter contrast; Animals; Biomedical imaging; Biomedical measurements; Diffusion tensor imaging; Embryo; Humans; Magnetic resonance imaging; Mice; Radiology; Tensile stress;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.259388
