Title :
The Influence of Activation Time on Contraction Force of Myocardial Tissue: a Simulation Study
Author :
Lu, Jianyin ; Nish, Toshifumi ; Ashihara, Takashi ; Schneider, Natalie S. ; Amano, Akira ; Matsuda, Tetsuya ; Kotera, Hidetoshi
Author_Institution :
Cell/Biodynamics Simulation Project, Kyoto Univ.
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
The efficiency of heart pump function greatly depends on synchronized contraction of myocardial muscle. In this work, contraction simulation of an excitable ventricular tissue cable was constructed to study the influence of excitation patterns on tissue contraction. The tissue cable is composed of elements which contract when excited by an external stimulus. In each calculation step, contraction force of each element is determined by a ventricular cell model. The mechanical deformation is then solved by finite element method and states of cells are updated accordingly. Several factors such as the starting position of the stimulation signal and the conduction velocity of gap-junctions affect contraction behavior. Simulation results show that the activation time, i.e. the time period the stimulation signal needs to spread over the tissue, is a dominant parameter for determining tissue contraction force. Contraction force of myocardial tissue increases monotonically with a decrease in activation time. This result suggests that minimization of activation time might be important for achieving effective tissue contraction
Keywords :
bioelectric phenomena; biomechanics; biomembrane transport; cardiology; deformation; finite element analysis; muscle; activation time; bio-simulation; conduction velocity; excitable ventricular tissue; excitation pattern; external stimulus; finite element method; heart pump function; heart simulation; mechanical deformation; myocardial muscle contraction; synchronized contraction; tissue contraction force; ventricular cell model; Biological system modeling; Biological tissues; Cities and towns; Computational modeling; Contracts; Finite element methods; Heart; Humans; Muscles; Myocardium; activation time; bio-simulation; heart simulation; myocardial tissue contraction;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.260804