Title :
Modelling of Acetylcholinesterase immobilized into artificial membrane
Author :
Santos, J. ; Friboulet, A. ; Lozano, R.
Author_Institution :
Jorge dos Santos & Rogelio Lozano, UMR-CNRS
fDate :
Aug. 30 2006-Sept. 3 2006
Abstract :
A model is developed for the investigation of an enzymatic diffusion-reaction system. The aim is to analyze the dynamic behavior of three different species, the modification of their enzymatic kinetic properties and the existence of complex behaviors resulting of the catalytic activity induced by immobilization of acetylcholinesterase into artificial membrane enzymatically inactive. We report results that make possible the characterization and prediction of complex behaviors as well as a qualitative/quantitative analysis of the system stability via bifurcation diagram which allows to study: i) the effect of the initial substrate concentration in the reservoir and ii) the effect of reaction-permeation modulus of the membrane as bifurcation parameters
Keywords :
bifurcation; biochemistry; biomembranes; catalysis; enzymes; molecular biophysics; neurophysiology; nonlinear dynamical systems; permeability; reaction kinetics theory; reaction-diffusion systems; acetylcholinesterase immobilization; artificial membrane; bifurcation diagram; catalytic activity; dynamic behavior; enzymatic diffusion-reaction system; enzymatic kinetic properties; reaction-permeation modulus; substrate concentration; Alzheimer´s disease; Bifurcation; Biochemistry; Biomembranes; Cardiac disease; Cities and towns; Inductors; Muscles; Neurotransmitters; USA Councils;
Conference_Titel :
Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE
Conference_Location :
New York, NY
Print_ISBN :
1-4244-0032-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2006.259430
